Updated: Jun 24, 2021
A conversation with Steve Munger, Assistant Professor at The Jackson Laboratory. Steve is a computational biologist with a passion for finding patterns in “big data”. Steve and his lab explore the natural genetic variation in each of us that makes us each unique, searching for patterns in our 3 billion bases of DNA that explain why some of us are more likely to get a specific disease than others. Using mice as a model, he seeks to discover how DNA mutations that assert subtle individual effects – “genetic paper cuts” – can, in certain combinations, disrupt gene regulatory networks, cellular function, and ultimately lead to disease.